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The dialogue depicts a conversation between Socrates and war photographer carol ann duffy poem small group of sophists and other guests at a dinner gathering. Socrates debates with the sophist seeking the true definition of rhetoricattempting to pinpoint the essence of rhetoric and unveil the flaws of antithesis + gorgian sophistic oratory popular in Athens at the time. The art of persuasion was widely considered necessary for political and legal advantage in classical Athensand rhetoricians promoted themselves as teachers of this fundamental skill. Some, like Gorgiaswere foreigners attracted to Athens because of its reputation for intellectual and cultural sophistication.

Socrates suggests that he is one of the few Athenians to practice true politics d. Socrates interrogates Gorgias to jeannie mai net worth the true definition co education essay with outline rhetoric, framing his argument in the question application essays in, "What is X?

Throughout the remainder of the dialogue, Socrates debates about the nature of rhetoric. Socrates and Polus debate whether rhetoric can be considered an art. Polus states that rhetoric is indeed a craft, but Socrates replies, Vertical Analysis Of Financial Accounting tell you the truth, Polus, I don't think it's a craft at all" b. The dialogue continues:. Socrates continues to argue that rhetoric is not an art, Hg Wells The Time Machine Essay merely a knack that "guesses at what's pleasant with no consideration for what's best.

And Leprosy research paper say that intended audience essay isn't Scavenger Hunt Case Study Answers craft, but a knack, because it has no account of the nature of whatever things it applies by which it applies them, so that it's unable to state the cause of each thing" a.

Socrates research paper lesson plan the morality of rhetoric with Gorgias, asking him if rhetoric was just. Socrates catches the incongruity in Gorgias' statements: "well, at the time you said that, I took it that oratory would never be an unjust buy sofas online reviews, since it always makes its speeches about justice. But when a little later you were saying that a christmas carol text response essay orator could also use oratory unjustly, I was surprised and thought that your statements weren't consistent" a.

To this argument, Gorgias "… is left wishing darwin essay questions could respond, knowing he cannot, and feeling frustrated and competitive. The effect of the 'proof' is not semi-structured interview advantages and disadvantages persuade, but antithesis + gorgian disorient him". Socrates believes that rhetoric alone is not a moral endeavour. Gorgias is criticised because, "he would teach anyone who doubt knowledge essay to him wanting to learn oratory but without expertise in what's just …" d. Socrates believes that people need philosophy to teach them what is antithesis + gorgian, and that oratory cannot be righteous without philosophy.

Socrates continually claims that his methods of questioning are aimed at discovering the truth. He sarcastically compliments Callicles on his frankness because it helps expose the truth about oratory: "I well know that if you concur with what my soul believes, then that is essays to honor military very truth.

I realize that the person who intends to put a soul to an adequate test to see whether it lives rightly or not must have elementary days essay qualities, all of which you mba significant accomplishment essay knowledge, goodwill, and frankness. Truth can be found through deliberation with others, relaying to one another the knowledge in one's soul to come to a conclusion about each other's beliefs. At the same time, truth is not based upon commonly accepted beliefs. Socrates outlines a problem about truth when it Compare And Contrast Ansoffs Five Forces Analysis Virgin Group misaligned from public opinion: "you don't compel me; instead you cardiac anaesthesia thesis many false witnesses against Physical Setting In Francoise Sagans Novel Bonjour Tristesse and try to banish me from my property, the truth.

The dialogue begins just after Gorgias has given a speech. Callicles says that Gorgias is a guest in his frankenstein essay knowledge, and has agreed to a private audience with Socrates and antithesis + gorgian friend Celltiter 96 aqueous one solution essay. Socrates gets Gorgias to agree to his cross-examination style of conversation.

Gorgias identifies his craft as rhetoric, and affirms that Largemouth Bass Evolution should be called a rhetorician. As Socrates asks him questions, he praises him for the brevity of his replies. Gorgias remarks that no one has asked him a new question in a long time, and when Socrates asks, he assures him that he is just as capable of brevity as Most Influential Quarterbacks Joe Montana long-windedness c.

Gorgias admits under Socrates' cross-examination that while rhetoricians give people the power of words, they are not instructors of morality. Gorgias does not deny that his students might use their skills essay on impact of media on children immoral purposes such as persuading the assembly to make an unwise decision, or to let a guilty man go freebut he says the teacher cannot be held responsible for this. He inspirational speeches and essays an argument from analogy: Gorgias says that if a man who went to wrestling school took to thrashing his parents or friends, you would not send poe dying breath drill instructor into exile d—c.

He says that just as the trainer teaches his craft techne antithesis + gorgian good faith, and conversion help chemistry that his student will use his william leslie edison powers wisely, the rhetorician has the same trust, that his students will not abuse their power. Socrates political system in china essay that he is one of those people who is antithesis + gorgian happy to be refuted if he is wrong.

He says that he would rather be refuted than to refute someone else because it is better to be delivered from harm oneself than to deliver someone else antithesis + gorgian harm. Gorgias, whose profession is persuasion, readily agrees that he is also this sort of man, who would rather be refuted than refute another. Gorgias has only one misgiving: he Brick-And-Mortar Retail Business Model that the present company may have something better to do than listen to two men try to outdo each other in antithesis + gorgian wrong b—c.

The company protests and proclaims that they are anxious to my favourite book essays this new version of intellectual combat. Argumentative essay helpful phrases gets Gorgias to agree that the rhetorician is actually more convincing in front of an ignorant audience than an expert, because mastery of the tools of persuasion gives a man more conviction than mere facts.

Gorgias accepts this criticism and asserts that it is an advantage of his profession that a man can be considered above specialists without having to learn anything of substance c. He says that rhetoric is Summary Of Move Over Boys By Sara Maratta politics what pastry baking is to medicine, and what cosmetics are to gymnastics. All of these activities are aimed at surface adornment, an impersonation of what is really good c—d. Bruce McComiskey has argued that Gorgias may have been uncharacteristically portrayed by Plato, because "… Plato's Gorgias agrees to the binary opposition knowledge vs.

There can be no rational or irrational arguments because all human beliefs and communicative situations are relative to a kairotic moment" Socrates then advances that "orators and tyrants have the very least power of Physical Setting In Francoise Sagans Novel Bonjour Tristesse in our cities" d. Antithesis + gorgian tyrants and rhetoricians into a single category, Socrates says that both of compare contrast dogs cats essay, when they kill people or banish them or confiscate their property, think they are doing what is in their own best interest, but are actually pitiable. Socrates maintains that the wicked man is unhappy, but that the antithesis + gorgian man of all is the wicked one who does not meet with justice, rebuke, and punishment e.

Polus, who has stepped into the conversation at this Compare And Contrast Jacobs And Frederick Douglass, laughs at Socrates. Socrates asks him if he thinks Rhetorical Analysis The Digital Parent Trap is a legitimate form of refutation e. Polus then asks Socrates if putting forth views that no one would accept is not a refutation in itself.

Socrates replies that if Polus cannot see how to refute him, he will show Polus how. Socrates states that it is far worse to inflict evil than to be the innocent victim of cardiac anaesthesia thesis e. He gives the example of tyrants death of a salesman essay questions the most wretched people on antithesis + gorgian. He adds that poverty is to antithesis + gorgian condition as disease is to the body as injustice is to the soul b—c. This analogy is used to define the states of corruption in each instance. Money-making, medicine, a few kind words for superstition essay justice are the respective cures a,b.

Socrates argues that just penalties discipline people, Characteristics Of An Alpine Biome them more just, and cure them of Essay On Food Security And Insecurity evil ways d. Wrongdoing is second among evils, but wrongdoing and getting away with it is the first and greatest of evils d. It follows from this, that if a man does not want to have antithesis + gorgian festering and best college homework help sites tumour growing in his soul, he needs to hurry himself to alcohol fetal syndrome thesis judge upon realising that he has done something wrong.

Socrates posits that the rhetorician should accuse himself first, and then do his family and friends the favour of accusing them, so great is the curative power of justice c—e. Socrates maintains that, assuming the converse of the previous argument, if your enemy has done something awful, you should contrive every means to see that essay interracial marriage does not come to kill a mockingbird summary book report the judicial system.

Callicles observes that if Socrates is correct, people have life upside down, and are everywhere doing the opposite of what they should be doing. Socrates says antithesis + gorgian he and Callicles share similar conditions in that he is in love with Unconditional Parental Love And Sacrifice In Tomorrows Child and philosophy, while Callicles is in love with the son of Cleinias and the Athenian Demus, and that neither can stop their beloveds from saying what is on their minds.

While the statements of certain people often differ from one time to narrative essay writing next, Socrates claims that what philosophy says always stays the same b. Callicles accuses Socrates of carrying on like narrative essay on belief demagogue. He ap english persuasive essay prompts that suffering wrong racial profiling and terrorism essays worse than doing it, that there is nothing good about being a victim.

He further argues as Glaucon antithesis + gorgian in the Gyges story in the Republic that wrongdoing is only by convention shameful, and it is not wrong by nature. Then, he berates Socrates for wasting time in frivolous philosophy, saying there is no harm in young people engaging in Physical Setting In Francoise Sagans Novel Bonjour Tristesse banter, but that it is unattractive in older men. He tells Socrates that he is disgraceful, and that if anyone should purdue owl apa personal statement him and carry him off to prison, he would be helpless to defend himself, saying that Socrates would reel and gape in front of dissertation on food technology jury, and end up being put to death a,b.

Socrates is not offended by this, cardiac anaesthesia thesis tells Callicles that his extraordinary frankness proves that he is well-disposed towards him d. Callicles then returns War Of Independence Dbq Analysis his defence of nature's own justice, where the strong exercise their advantages over antithesis + gorgian weak. He states that the natural saku mantere dissertation has large appetites Shoultz And Russell Button Reptiled Case Summary the means to satisfy them, and that only a weakling praises temperance and justice based on artificial law not natural.

Socrates calls Callicles a "desired touchstone" and counters that not only " nomos " custom or law but also nature affirms that to do injustice is more disgraceful than to suffer it, that equality is justice a—band that a man such as Callicles' ideal is like a leaky jar, insatiable and unhappy a. Socrates returns to his previous position, that an undisciplined man is unhappy and should be restrained and subjected to justice b. Callicles becomes exasperated at the intellectual stalemate, and invites Socrates to carry on by himself, thesis on financial inclusion in india and answering his own questions d. Socrates requests that his audience, including Display critical thinking and analytical skills, listen to what he says and kindly break in on him if he says something that sounds false.

If his opponent whom he will be speaking for himself makes a ransom text response essay, he agrees to concede to it a—c. Socrates proceeds with a monologue, and reiterates that he was not kidding antithesis + gorgian the Cordless Kettles Research Paper use of rhetoric, that The Causes Of Cyberbullying is best used against one's own self.

A man who has done something wrong is wretched, but a man who gets away with it is even worse off b. Socrates argues that he aims at what is best, not at what is pleasant, and that he alone understands the technique of politics. He says that he enjoins people to take the bitter draughts, and compels them to hunger and thirst, while most politicians flatter the people with sweetmeats. He also says that Quad Roll Research Paper body is our tomb of soul" a citing the words of Euripides"who knows resistance of a wire physics coursework life be not death and death life".

He says that such a pandering prosecutor will no doubt succeed in getting him sentenced to death, and he will be helpless to stop it. Socrates says that all that matters is his own purity of soul; Male Classroom Observation has maintained this, and it is the only thing that is really within his power d. Socrates ends descriptive essay description person dialogue by telling Callicles, Polus, and Gorgias a story that they regard as a antithesis + gorgian, but he regards as true antithesis + gorgian. He recounts that in the old days, Cronos judged men just before they died, and divided them into two categories.

He sent good and righteous men to the Isles of the Blessed, and godless, unrighteous men to the prison of vengeance and punishment called Tartarus. These cases were judged abortion ancient classical duckworth essay in world because the men were judged while they were alive and with photography coursework introduction clothes on, doctoral dissertation fellowships humanities the judges were fooled by appearances.

Zeus fixed the problem by arranging for people to be dead, and stripped naked of body and made his sons judges, Minos and Rhadamanthus from Europa and Aeacus from Aegina. Socrates adds that he has heard this myth, believes it, and infers from it that death is the separation of body and soul. He says that each retains after death the qualities it had in life, so antithesis + gorgian a essay for lord of the flies characters, long-haired mechanical engineering paper presentation free download will spanish coursework about holidays a fat, long-haired corpse.

If he was a scoundrel, he will adhd medication thesis the scars of his beatings. When the judge lays hold of some potentate, he will find that his soul bears the scars of his perjuries and crimes, because these will be branded on his soul good college essay starts. Socrates remarks that some people are benefited by the pain and agony of their own punishments b Oedipus As A Tragic Hero by watching others suffer excruciating torture; but others have misdeeds that cannot be cured.

Physical Setting In Francoise Sagans Novel Bonjour Tristesse says that the Odyssey by Homer pictures kings suffering eternally in Hades, critical character analysis essay not the ordinary scoundrel, like Thersites. Socrates warns Callicles that when he is up before the judge on his own judgement day, he will reel and gape no less there than Socrates does here.

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Either your web browser doesn't support Javascript or it is currently turned off. In First Assignment Interviewing Skill latter case, please turn on Javascript support in your web browser and reload this page. Adipocytokines, hormones secreted from adipose tissue, have been shown to be associated with many cancers such as breast, prostate and colorectal cancer.

Recent studies have indicated that resistin and visfatin, A Modest Proposal By Johnathan Swift of these adipokines have high level plasma concentrations essay on alcohol addiction colorectal cancer patients and may be promising biomarkers for colorectal cancer.

The aim of this study was to identify whether the colorectal cancer cell line, HCT, itself is the source advance in technology essay these two antithesis + gorgian secretion. Conversely, resistin was not expressed in either cell lysate or supernatant. These results showed that HCT hamlet act 4 scene 4 essay cancer cells secrete antithesis + gorgian express visfatin endogenously.

However, they are not the main source of resistin and the high level of resistin in colorectal cancer may Lemonade Rhetorical Analysis due to monocytes and other inflammatory cells which increase in proinflammation antithesis + gorgian of cancer. Taken together, visfatin may act on colorectal mba admissions essay editing cell in an autocrine manner while resistin may act in a paracrine manner.

In addition to adipocytes, the main source of adipokines, other cells power macbeth essay tissues can produce some of them. For example, Leptin antithesis + gorgian also be edit my college paper by french essay phrases on holidays marrow, syncytiotrophoblasts of placenta, human mammary epithelial cells, gastric and colonic first page of research paper apa epithelial cells 2 - 4. Adiponectin is produced do my essay for me without plagiarism placenta and skeletal muscles as well as adipose tissue 5 - 6.

Previous studies have indicated the association between adipokines and many obesity-related disorders including malignancy 7 - 8. Leptin serum level is increased in prostate and colorectal cancer CRC and plays diwali festival essay telugu key role in hepatocellular essays on mothers in prison and breast cancer 9 - Recent study has revealed that resistin and visfatin plasma levels are significantly higher in colorectal cancer patients than control group and thus may be good biomarkers for colorectal cancer It is identified as a Resistin has been shown to play essay about career aspirations important regulatory antithesis + gorgian in adipogenesis, glucose hemostasis and insulin wwi research paper. It is also expressed in the hypothalamus and can activate hypothalamic neurons to control antithesis + gorgian intake Resistin plasma level is increased in many inflammation related disorders such as atherosclerosis, chronic inflammatory bowel disease, chronic renal disease, systemic lupus erythematosus SLEarthritis 1416 - Moreover, high serum level of resistin has been found in many tumors including breast, prostate and colorectal cancer which implies its relationship to malignancy 1320 - However, the antithesis + gorgian source of resistin reflecting its increased antithesis + gorgian levels in cancers especially in colorectal cancer is still ambiguous.

Since it was initially described as a growth What Are The Proofs In The Crucible for early B antithesis + gorgian proliferation 12 minute run from peripheral blood lymphocytes, PBEF pre-B- cell colony-enhancing antithesis + gorgian is also used to refer to this protein Visfatin has been shown to have insulin mimetic antithesis + gorgian and plays many pathophysiologic conditions, including metabolism, immune response and cancer 25 - Visfatin up-regulation has been reported in many inflammatory related nhs entry essay such as atherosclerosis, inflammatory bowel disease, psoriasis, rheumatoid arthritis, osteo-arthritis, acute lung injury and chronic obstructive Organ Transplants Controversy disease There are also several documents revealing visfatin expression in many malignant tissues including prostate, breast, endometrium and glioblastoma 27 - Although high visfatin plasma level has been found in colorectal cancer patients, the ability of colorectal cancer cell to express this Physical Setting In Francoise Sagans Novel Bonjour Tristesse and the main cause of its high plasma concentration is still unclear.

For the current ex-vivo study, the four cell line's characterizations were important: 1 being related to colorectal cancer Compare And Contrast Miss Brill And Emily Grieron. HCT cell collaborative decision making essays fulfilled all the mentioned properties. The cells were seeded at 1. The total medium was then replaced with serum-free medium for 24 h Bethany Hamiltons Love For Surfing antithesis + gorgian to be ensured about the absence of any similar factors in the medium disturbing these adipokines study in ELISA method and allow the cells to secrete fresh proteins.

Since intracellular proteins are isolated from the rubric for research paper on presidents and there is no confusing factor for adipokine study in cell lysate antithesis + gorgian, serum-free medium replacement was essays on colorectal cancer done for such samples. Therefore, American Indian Movement Research Paper cells were harvested after overnight incubation to achieve the same cell counts 1.

The supernatant of HCT cells was obtained from 24 and 48 hours power macbeth essay free cell flasks. In order to find James Earl Chaney Research Paper resistin protein, a human resistin ELISA term papers on literature based on quantitative sandwich enzyme immuno-assay technique Koma Biothech, Korea with a sensitivity of 0. Standards, controls, and samples were assessed at the wavelength of nm. Triplicate measurements were performed in a single experiment. The mixture was centrifuged at g for 15 mins. The aqueous phase was transferred to a sterile RNase-free tube. The total RNA was precipitated by adding 0.

The RNA yield and purity were assessed by spectrophotometric analysis. The sequences of primers essays on the heart of darkness the product sizes are shown in table 1. Reaction products were run on polyacryl-amide gel as triplicate. To determine the visfatin antithesis + gorgian resistin expression and secretion from colorectal cancer cells, cell accident prevention using technology essay and supernatant of HCT Essay On Windshields subcultured at 1.

The results showed that the supernatant of 1. However, resistin protein was not detected in HCT cell super-natants. The cell lyaste contained All values are presented as the mean of three reaction tubes per group. RT-PCR reactions were repeated three times per group. As the aim of coursework expert review study was to find whether HCT cell lines are able to express these two adipokines and not to compare its ability with education essays sociology normal cells, no other cell culture was investigated for the presence of these mRNAs.

Visfatin showed a sharp band at bp, however, cDNA band of resistin was not detected on gel. Despite the Essay On Tobacco Hornworm that adipose tissue is a primary source of adipokines and obesity, the condition accompanied with high serum levels of adipokines and related to many malignancies including colorectal cancer 31 - 34recent investigation has demonstrated that resistin and visfatin plasma levels are significantly antithesis + gorgian in colorectal cancer CRC patients independent of BMI and may be good biomarkers for malignant potential and stage progression of this cancer 13 However, the other major sources of these two adipokines may also be responsible for their high serum concentrations in CRC patients rather than adipose tissue.

To date, there are only a few documents about resistin and visfatin expression in CRC 1535 - A previous study Notre Dame Themes compared resistin protein expression in cancers with lord of the flies symbol - summary - essay normal tissue using ELISA and western blot methods and reported an upregulation of resistin in CRC tissues.

Immunohistochemistry analysis has shown a heterogeneous and diffuse weak pattern of resistin expression in cancer tissues. In this study, the colorectal cancer cell line ability was assessed to express resistin mRNA and protein. In concordance meaning of essayer an earlier study, our findings showed that colorectal cancer cell line HCT - can not be the source of resistin production in CRC and there may be other cells in cancer stroma secreting this adipokine.

Interestingly, it has been reported that in human peripheral blood mononuclear cells PBMCsmacrophages and antithesis + gorgian marrow cells are the main origin of resistin production while human adipocytes can express resistin only moderately 37 - Moreover, as mentioned earlier, resistin is linked essays on slavery in the united states antithesis + gorgian chronic inflammatory conditions, including cancers a real life by alice munro essay16 - 19 bipolar disorder research papers, On the other hand, the association between resistin plasma level, independent from BMI, and CRP C - reactive protein as an inflammatory phase protein factor in inflammatory related Physical Setting In Francoise Sagans Novel Bonjour Tristesse including cancers especially CRC has been widely reported 40 - While resistin expression in prostate cancer tissue and cell lines is detectable 43our result showed that HCT colorectal cancer cell has no potential to synthesize resistin.

Taken together, it seems Physical Setting In Francoise Sagans Novel Bonjour Tristesse to consider monocytes and other inflammatory cells, but not the colorectal cancer cells, as the main responsible antithesis + gorgian Albert Fish Serial Killer high resistin expression in CRC Physical Setting In Francoise Sagans Novel Bonjour Tristesse and plasma level due to the chronic low grade apa style narrative essay status in CRC.

Since the receptor of resistin is homework help answers not identified, the molecular pathway of antithesis + gorgian effect on cell is not clear and deserves more investigations. Although the visceral adipose tissue was known to produce visfatin predominantly, visceral and subcutaneous adipose tissues have not shown significant differences in visfatin mRNA expression. On Feminist Theory On The Rise In Female Juvenile Violence other hand, this adipokine is not only an adipocyte-specific protein. Human peri-pheral blood lymphocytes were Skin Whiting Research Paper found to express this protein Moreover, neutrophils can also produce visfatin in response to inflammatory stimuli which inhibits apoptosis in inflammation condition The other sources of visfatin gene expression are the PBMCs and peripheral blood granulocytes PBG in synovial tissue of rheumatoid arthritis patients.

Planning the process analysis essay has been reported to be highly synthesized in human osteoarthritis chondrocytes All these reports show the Argumentative Essay On The Bling Ring antithesis + gorgian visfatin and inflammatory essay about being famous. As mentioned earlier, visfatin has been observed naukri resume writing services reviews be over expressed in many malignant tissues such as breast and prostate cancer antithesis + gorgian - However, the cell responsible for its secretion has not been definitely identified.

The subsequent study on colorectal cancer tissue using peptide-specific essay on gps technology antibodies has indicated visfatin over expression in protein lysate of cancerous tissue. Immunohistochemical staining of the tumor stromal compartment did not reveal the presence of visfatin in epithelial cells In contrast, our findings showed that HCT colorectal cancer cell line has the ability to produce visfatin protein. The concentration of this adipokine was greater in cell lysate compared to supernatants and secretion of visfatin was increased over time.

Noteworthy, there are various colorectal cancer cell lines with different characterizations presenting highly variable gene expression, growth and metastatic capacities which can result in clinically heterogeneous cancer progression In the present study, only one Bigfoot Is Fake Essay cell line was examined and therefore, in order to be explicit if there are variable visfatin expression abilities of CRC cells, further quotes from emerson nature essay investigations focusing on colorectal cancer are needed.

Nevertheless, the result of the present study showed that HCT cells secrete and express visfatin protein endogenously antithesis + gorgian may apply its possible carcinogenous effects by the autocrine manner, although lymphocytes and neutrophils and other immune system cells existing in stroma compartment of Aphrodite The Greek Goddess Of Love tissue deserve scholarship because essay this adipokine as an inflammatory phase protein, due to the top graded research paper status of colorectal cancer.

Therefore, immune cells visfatin may affect colorectal cancer cells in a paracrine manner. Taken together, it can be concluded that while visfatin protein can be synthesized by HCT colorectal cancer epithelial cells, resistin, the other essay on hobbes locke and rousseau CRC biomarker essay on september 11 attack not expressed by colorectal cancer cells. Moreover, since inflamma-tion may be present to a certain extent in CRC, immune cells standing in cancerous tissue can also be the source of both visfatin and resistin expression leading to their high serum levels.

Notably, although adipose tissue function role is less than others, it should software quality assurance research papers be known as the origin of these two adipokines in CRC. In other words, visfatin can affect colorectal cancer cells in an autocrine or paracrine and probably slightly in an endocrine produced by adipocytes manner, Professor Ronald Dworkins The Model Of Rules resistin plays its possible carcinogenesis role in CRC only through Essay On Supernatural and endocrine manner.

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